Die folgenden Treiber implementieren momentan die PDO-Schnittstelle:
| Treibername | Unterstützte Datenbanken | 
|---|---|
| PDO_DBLIB | FreeTDS / Microsoft SQL Server / Sybase | 
| PDO_FIREBIRD | Firebird/Interbase 6 | 
| PDO_IBM | IBM DB2 | 
| PDO_INFORMIX | IBM Informix Dynamic Server | 
| PDO_MYSQL | MySQL 3.x/4.x | 
| PDO_OCI | Oracle Call Interface | 
| PDO_ODBC | ODBC v3 (IBM DB2, unixODBC und win32 ODBC) | 
| PDO_PGSQL | PostgreSQL | 
| PDO_SQLITE | SQLite 3 und SQLite 2 | 
It should be noted that PDO ODBC works with the iODBC driver manager (default for Mac OS X and some other environments, and optional on most non-Windows platforms) as well as with UnixODBC and Windows ODBC.